Two brain cholecystokinin receptors: implications for behavioral actions

Brain Res. 1986 Jan 1;362(1):175-9. doi: 10.1016/0006-8993(86)91413-7.


The distribution and relative specificity of cholecystokinin (CCK) receptors in the rat brain was mapped by in vitro autoradiography with [125I]CCK-33. We identified two distinct binding patterns, suggesting two CCK receptor types. The first is widespread and relatively non-specific. The second, localized to a few subcortical nuclei, has the specificity demonstrated for pancreatic CCK receptors. Localization of this receptor type to the area postrema provides a possible entry site into brain for circulating CCK that would distinguish between CCK and gastrin and could mediate some of CCK's behavioral effects.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Autoradiography
  • Behavior, Animal / physiology*
  • Brain / metabolism*
  • Male
  • Rats
  • Rats, Inbred Strains
  • Receptors, Cell Surface / classification
  • Receptors, Cell Surface / metabolism*
  • Receptors, Cell Surface / physiology
  • Receptors, Cholecystokinin
  • Tissue Distribution


  • Receptors, Cell Surface
  • Receptors, Cholecystokinin