Rab GTPase Function in Endosome and Lysosome Biogenesis

Trends Cell Biol. 2018 Nov;28(11):957-970. doi: 10.1016/j.tcb.2018.06.007. Epub 2018 Jul 17.


Eukaryotic cells maintain a highly organized endolysosomal system. This system regulates the protein and lipid content of the plasma membrane, it participates in the intracellular quality control machinery and is needed for the efficient removal of damaged organelles. This complex network comprises an endosomal membrane system that feeds into the lysosomes, yet also allows recycling of membrane proteins, and probably lipids. Moreover, lysosomal degradation provides the cell with macromolecules for further growth. In this review, we focus primarily on the role of the small Rab GTPases Rab5 and Rab7 as organelle markers and interactors of multiple effectors on endosomes and lysosomes and highlight their role in membrane dynamics, particularly fusion along the endolysosomal pathway.

Keywords: GEF; Rab GTPase; SNARE; coiled-coil; endosome; lysosome; tether.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers / metabolism
  • Endosomes / enzymology*
  • Endosomes / genetics
  • Endosomes / metabolism*
  • Humans
  • Lysosomes / enzymology*
  • Lysosomes / genetics
  • Lysosomes / metabolism*
  • rab GTP-Binding Proteins / metabolism*


  • Biomarkers
  • rab GTP-Binding Proteins