Calculation of relative glomerular filtration rate and correlation with delayed technetium-99m DMSA imaging

Clin Nucl Med. 1986 Jan;11(1):28-31. doi: 10.1097/00003072-198601000-00010.


The relative renal uptake of Tc-99m DMSA was compared with the relative glomerular filtration rate (GFR) in ten patients with serum creatinines ranging from 0.3 to 2.5 mg/dl. Relative GFR was based on the renal uptake of Tc-99m DTPA determined by two methods: 1) integrating the counts from 1 to 3 minutes postinjection and correcting for background. 2) Totalizing the individual renal counts in a single 15-second frame from 2:45 minutes to 3:00 minutes postinjection and correcting for background. The two methods of determining relative DTPA uptake showed excellent correlation, r = 0.98. Relative DMSA uptake determined at 24 hours post-injection using computer-assisted regions of interest showed excellent correlation with the relative GFR determined by either the integral or single-frame method, r = 0.98. The addition of background subtraction for the DMSA images at 24 hours did not improve the correlation.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Child, Preschool
  • Computers
  • Creatinine / blood
  • Female
  • Glomerular Filtration Rate*
  • Humans
  • Kidney / diagnostic imaging*
  • Male
  • Methods
  • Pentetic Acid
  • Radionuclide Imaging
  • Succimer*
  • Sulfhydryl Compounds*
  • Technetium Tc 99m Dimercaptosuccinic Acid
  • Technetium Tc 99m Pentetate
  • Technetium*
  • Time Factors


  • Sulfhydryl Compounds
  • Technetium Tc 99m Dimercaptosuccinic Acid
  • Technetium
  • Pentetic Acid
  • Creatinine
  • Succimer
  • Technetium Tc 99m Pentetate