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. 2018 Sep;48(9):1592-1594.
doi: 10.1002/eji.201747452. Epub 2018 Aug 22.

Kallikrein-related Peptidases Are Activators of the CC Chemokine CCL14

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Kallikrein-related Peptidases Are Activators of the CC Chemokine CCL14

Mario Grünberg et al. Eur J Immunol. .
Free article

Abstract

Chemokine CCL14 is inactive in its proform. Here, we show that inflammation- and cancer-associated kallikrein-related peptidases KLK5 and KLK8 remove the N-terminal eight amino acids from the proform thereby converting CCL14 to its active state. Activity of the chemokine is demonstrated by migration of myeloid cells expressing relevant receptors.

Keywords: CCL14; THP-1; chemokines; myeloid cells.

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