Incorporation of synthetic 1,2-diacylglycerol into platelet phosphatidylinositol is increased by cyclic AMP

FEBS Lett. 1986 Jan 20;195(1-2):111-4. doi: 10.1016/0014-5793(86)80141-7.

Abstract

1,2-Didecanoylglycerol (diC10) is taken up by human platelets and sequentially converted to 1,2-didecanoylphosphatidic acid (PA10) and 1,2-didecanoylphosphatidylinositol (PI10). Agents that increase cyclic AMP in platelets, such as prostacyclin and forskolin, sequentially convert diC10 to PA10 and PI10. They decrease formation of PA10 with a parallel accumulation of PI10. This might reflect an inhibition of phosphatidylinositol kinase.

MeSH terms

  • Blood Platelets / metabolism*
  • Colforsin / pharmacology
  • Cyclic AMP / pharmacology
  • Diglycerides / metabolism*
  • Epoprostenol / pharmacology
  • Glycerides / metabolism*
  • Humans
  • Phosphatidic Acids / metabolism
  • Phosphatidylinositols / metabolism*

Substances

  • Diglycerides
  • Glycerides
  • Phosphatidic Acids
  • Phosphatidylinositols
  • Colforsin
  • Epoprostenol
  • Cyclic AMP