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, 71 (2), 197-199

Spoon-Feeding Ribosomes to Autophagy


Spoon-Feeding Ribosomes to Autophagy

Hitoshi Nakatogawa. Mol Cell.


The ribosome, a ribonucleoprotein machine for protein synthesis, can also serve as an abundant nutrient source under starvation conditions. In a recent issue of Science, Wyant et al. (2018) discovered a specialized "spoon" to "scoop up" more ribosomes for degradation by autophagy.

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  • NUFIP1 is a ribosome receptor for starvation-induced ribophagy.
    Wyant GA, Abu-Remaileh M, Frenkel EM, Laqtom NN, Dharamdasani V, Lewis CA, Chan SH, Heinze I, Ori A, Sabatini DM. Wyant GA, et al. Science. 2018 May 18;360(6390):751-758. doi: 10.1126/science.aar2663. Epub 2018 Apr 26. Science. 2018. PMID: 29700228 Free PMC article.

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