The pathogenesis of thoracic aortic aneurysm from hereditary perspective

Lifei Wu

doi:10.1016/j.gene.2018.07.047

The pathogenesis of thoracic aortic aneurysm from hereditary perspective

Gene. 2018 Nov 30:677:77-82. doi: 10.1016/j.gene.2018.07.047. Epub 2018 Jul 18.

Author

Lifei Wu¹

Affiliation

¹ Basic Medical College, Shanxi Medical University, 030001, China. Electronic address: lifeiwu891002@sxmu.edu.com.

PMID: 30030203
DOI: 10.1016/j.gene.2018.07.047

Abstract

Thoracic aortic aneurysm is extremely threatening due to high risk of dissection and rupture. Genetic factors play decisive role in the pathogenesis of thoracic aortic aneurysm. Recent years, several genes are considered to be associated with thoracic aortic aneurysm, among these genes, 11 gene variants identified are responsible for thoracic aortic aneurysm. In this review, we mainly discussed the function of the 11 gene variants in thoracic aortic aneurysm and the histology and cytokine signaling alterations induced by these gene variants.

Keywords: Gene; Thoracic aortic aneurysm; Variants.

Publication types

Review

MeSH terms

Animals
Aortic Aneurysm, Thoracic / genetics*
Aortic Aneurysm, Thoracic / pathology*
Cytokines / genetics
Genetic Variation / genetics
Humans

Substances

Cytokines