The Three-Dimensional Organization of the Genome in Cellular Senescence and Age-Associated Diseases

Semin Cell Dev Biol. 2019 Jun;90:154-160. doi: 10.1016/j.semcdb.2018.07.022. Epub 2018 Jul 27.

Abstract

Recent advances in genomics and imaging technologies have increased our ability to interrogate the 3D conformation of chromosomes and to better understand principles of organization and dynamics, as well as how their alteration can lead to disease. In this review we describe how these technologies have shed new light into the role of the 3D organization of the genome in defining cellular states in aging and age-associated diseases. We compare the genomic organization in cellular senescence and cancer, discuss the role of the lamina in maintaining the structural and functional integrity of the genome, and we highlight the recent findings on how this organization breaks down in disease states.

Keywords: Aging; Cancer; Cytoplasmic DNA; Hi-C; Inflammation; Senescence.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / genetics*
  • Aging / pathology*
  • Cellular Senescence / genetics*
  • Humans
  • Neoplasms / genetics*