[Baclofen inhibition of synaptic transmission in glomeruli of the olfactory bulb of the frog]

Neirofiziologiia. 1985;17(6):834-7.
[Article in Russian]

Abstract

The application of (+/-) baclofen (10(-5) M) to the frog olfactory bulb greatly reduced postsynaptic components of the orthodromic potential, but the antidromic potential was not affected. The effect was not antagonized by bicuculline (10(-4)-10(-3) M). The results suggest that bicuculline-insensitive GABAB-receptors are located on the primary olfactory afferents and may realize presynaptic inhibition in the olfactory bulb.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Baclofen / pharmacology*
  • Bicuculline / pharmacology
  • Depression, Chemical
  • Membrane Potentials / drug effects
  • Olfactory Bulb / drug effects*
  • Rana temporaria
  • Receptors, GABA-A
  • Synapses / drug effects
  • Synaptic Transmission / drug effects

Substances

  • Receptors, GABA-A
  • Baclofen
  • Bicuculline