Anticoagulation Reversal

Emerg Med Clin North Am. 2018 Aug;36(3):585-601. doi: 10.1016/j.emc.2018.04.014.


Today a variety of anticoagulants and antiplatelet agents are available on the market. Given the propensity for bleeding among patients prescribed these medications, the emergency medicine physician must be equipped with a working knowledge of hemostasis, and anticoagulant and antiplatelet reversal. This article reviews strategies to address bleeding complications occurring secondary to warfarin, low-molecular-weight heparin, and direct oral anticoagulant therapy.

Keywords: Anticoagulant reversal; Heparin; Idarucizumab; Novel oral anticoagulants; Prothrombin complex concentrate; Warfarin.

Publication types

  • Review

MeSH terms

  • Anticoagulants / adverse effects*
  • Anticoagulants / therapeutic use
  • Hemorrhage / chemically induced
  • Hemorrhage / therapy*
  • Hemostatic Techniques*
  • Humans
  • Thromboembolism / drug therapy*


  • Anticoagulants