Genital condylomas in immunosuppressed women: a therapeutic challenge

South Med J. 1986 Feb;79(2):183-7. doi: 10.1097/00007611-198602000-00012.


Of 30 immunosuppressed women with genital condylomas, 20 (67%) had associated neoplasia of the lower genital tract. We retrospectively studied 11 patients with flat condylomas confined to the cervix; all lesions were eradicated by conventional therapy. Three patients studied retrospectively and 16 studied prospectively had condylomatous lesions involving several sites within the lower genital tract. These lesions were unusually resistant to various treatment methods. Maintenance therapy with 5-fluorouracil (5-FU) cream resulted in a significantly higher control rate (6/7 patients, 86%) than could be achieved otherwise (2/9 patients, 22%; P less than .025). We conclude that ablative therapy by surgery or topical chemical agents followed by maintenance therapy with 5-FU cream may be the treatment of choice for condylomas and other human papillomavirus-associated lesions of the lower genital tract in immunosuppressed women.

MeSH terms

  • Adult
  • Antineoplastic Agents / therapeutic use
  • Combined Modality Therapy
  • Condylomata Acuminata / therapy*
  • Female
  • Fluorouracil / therapeutic use
  • Genital Neoplasms, Female / therapy*
  • Humans
  • Immune Tolerance*
  • Immunosuppression Therapy / adverse effects
  • Laser Therapy
  • Middle Aged
  • Papillomaviridae
  • Prospective Studies
  • Retrospective Studies
  • Tumor Virus Infections / therapy
  • Uterine Cervical Neoplasms / therapy


  • Antineoplastic Agents
  • Fluorouracil