Laetrile intoxication and hepatic necrosis: a possible association

South Med J. 1986 Feb;79(2):259-60. doi: 10.1097/00007611-198602000-00034.


A 65-year-old woman with cirrhosis and hepatoma lapsed into deep coma, hypotension, and acidosis after ingestion of 3 gm of Laetrile, a cyanogenetic glucoside. After initial treatment, the patient regained consciousness, but massive hepatic damage led to her death. We suggested a possible relationship between Laetrile poisoning and massive hepatic necrosis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Amygdalin / poisoning*
  • Carcinoma, Hepatocellular / drug therapy
  • Female
  • Humans
  • Liver / pathology*
  • Liver Cirrhosis / drug therapy
  • Liver Neoplasms / drug therapy
  • Necrosis


  • Amygdalin