An atlas of IgE sensitization patterns in different Italian areas. A multicenter, cross-sectional study

Eur Ann Allergy Clin Immunol. 2018 Sep;50(5):217-225. doi: 10.23822/EurAnnACI.1764-1489.67. Epub 2018 Jul 24.


Background. The development of recombinant technology supported the allergy diagnostic work-up in the daily clinical practice, representing a useful tool for epidemiological studies. Methods. An atlas of the IgE sensitization profiles found throughout Italy was prepared from a nationwide, multicenter, cross-sectional study. Results. 6052 unselected consecutive individuals, belonging to North-West [NW], North-East [NE], Centre [C], South [S], and Islands subset [Is] were evaluated by means of the ImmunoCAP ISAC test. The top-ranked sensitizations found were Cup a 1 in [C] (58.1%) and [S] (53.6%), Phl p 1 in the North (from 46.1% to 49%), and Cyn d 1 in [Is] (44.2%). High frequency of house dust mite group 2 molecules sensitization was found in [C] (36.9%) and [S] Italy (40.8%), whilst low level of reactivity was recorded in [NW] (20%). Pellitory hypersensitivity was mainly found in [C], [S], and [Is], whilst ragweed Amb a 1 sensitivity was particularly found in [NW] Italy. IgE recognition of PR-10, Profilin, and nsLTP was mutually exclusive in 69.1% of cases, PR-10 reactivity mostly occurring in [NE], Profilin in [NW], and nsLTP molecules recognition mainly recorded in [C] and [S]. Conclusions. Divergent IgE sensitization patterns were found along Italy, possibly linked to the distinct geographical locations, indicating multiplex system IgE analysis as a reliable approach for epidemiological evaluation even in small geographical areas.

Keywords: PR-10; Profilin; epidemiology; microarray; nsLTP.

Publication types

  • Multicenter Study

MeSH terms

  • Adolescent
  • Adult
  • Allergens / genetics
  • Allergens / immunology
  • Cross-Sectional Studies
  • Diagnostic Tests, Routine
  • Female
  • Humans
  • Hypersensitivity / epidemiology*
  • Immunization / statistics & numerical data*
  • Immunoglobulin E / metabolism*
  • Italy / epidemiology
  • Male
  • Middle Aged
  • Recombinant Proteins / genetics
  • Recombinant Proteins / immunology
  • Young Adult


  • Allergens
  • Recombinant Proteins
  • Immunoglobulin E