A Global Perspective of Latent Autoimmune Diabetes in Adults

Rajashree Mishra; Kenyaita M Hodge; Diana L Cousminer; Richard D Leslie; Struan F A Grant

doi:10.1016/j.tem.2018.07.001

A Global Perspective of Latent Autoimmune Diabetes in Adults

Trends Endocrinol Metab. 2018 Sep;29(9):638-650. doi: 10.1016/j.tem.2018.07.001. Epub 2018 Jul 23.

Authors

Rajashree Mishra¹, Kenyaita M Hodge², Diana L Cousminer³, Richard D Leslie⁴, Struan F A Grant⁵

Affiliations

¹ Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Graduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; These authors contributed equally.
² Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; These authors contributed equally.
³ Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
⁴ Department of Immunobiology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AD, UK.
⁵ Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA; Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Electronic address: grants@email.chop.edu.

PMID: 30041834
DOI: 10.1016/j.tem.2018.07.001

Abstract

Latent autoimmune diabetes in adults (LADA) is characterized by the presence of islet autoantibodies and initial insulin independence, which can lead to misdiagnosis of type 2 diabetes (T2D). As such, understanding the genetic etiology of LADA could aid in more accurate diagnosis. However, there is ongoing debate regarding the exact definition of LADA, so understanding its impact in different populations when contrasted with type 1 diabetes (T1D) and T2D is one potential strategy to gain insight into its etiology. Unfortunately, the lack of consistent and thorough autoantibody screening around the world has hampered well-powered genetic studies of LADA. This review highlights recent genetic and epidemiological studies of LADA in diverse populations as well as the importance of autoantibody screening in facilitating future research.

Keywords: GAD65; adults; autoantibodies; diabetes mellitus; latent autoimmune diabetes.

Publication types

Review

MeSH terms

Adult
Autoantibodies / blood*
Humans
Latent Autoimmune Diabetes in Adults* / diagnosis
Latent Autoimmune Diabetes in Adults* / epidemiology
Latent Autoimmune Diabetes in Adults* / genetics
Latent Autoimmune Diabetes in Adults* / immunology

Substances

Autoantibodies