A Global Perspective of Latent Autoimmune Diabetes in Adults

Trends Endocrinol Metab. 2018 Sep;29(9):638-650. doi: 10.1016/j.tem.2018.07.001. Epub 2018 Jul 23.


Latent autoimmune diabetes in adults (LADA) is characterized by the presence of islet autoantibodies and initial insulin independence, which can lead to misdiagnosis of type 2 diabetes (T2D). As such, understanding the genetic etiology of LADA could aid in more accurate diagnosis. However, there is ongoing debate regarding the exact definition of LADA, so understanding its impact in different populations when contrasted with type 1 diabetes (T1D) and T2D is one potential strategy to gain insight into its etiology. Unfortunately, the lack of consistent and thorough autoantibody screening around the world has hampered well-powered genetic studies of LADA. This review highlights recent genetic and epidemiological studies of LADA in diverse populations as well as the importance of autoantibody screening in facilitating future research.

Keywords: GAD65; adults; autoantibodies; diabetes mellitus; latent autoimmune diabetes.

Publication types

  • Review

MeSH terms

  • Adult
  • Autoantibodies / blood*
  • Humans
  • Latent Autoimmune Diabetes in Adults* / diagnosis
  • Latent Autoimmune Diabetes in Adults* / epidemiology
  • Latent Autoimmune Diabetes in Adults* / genetics
  • Latent Autoimmune Diabetes in Adults* / immunology


  • Autoantibodies