LncRNA SNHG3 enhances the malignant progress of glioma through silencing KLF2 and p21

Biosci Rep. 2018 Sep 7;38(5):BSR20180420. doi: 10.1042/BSR20180420. Print 2018 Oct 31.


As a newly discovered long non-coding RNA, small nucleolar RNA host gene 3 (SHNG3) has been reported to be dysregulated in certain cancers. Nevertheless, the details about clinical values and biological effects of SNHG3 on glioma are still covered. In this paper, we determined the expression level of SNHG3 in glioma tissues and cells and evaluated the effect of SNHG3 expression on the prognosis of glioma patients. The functional assays were applied to define the effects of SNHG3 on the biological behaviors in glioma including cell proliferation, cell cycle, and apoptosis. It was revealed that SNHG3 was much more enriched in glioma tissues and cell lines than in normal ones. Furthermore, gain- or loss-of-function experiments indicated that the up-regulation of SNHG3 promoted cell proliferation, accelerate cell cycle progress, and repressed cell apoptosis. The mechanistic assays disclosed that SNHG3 facilitated the malignant progression of glioma through epigenetically repressing KLF2 and p21 via recruiting enhancer of zeste homolog 2 to the promoter of KLF2 and p21. Generally, it was exposed that SNHG3 might function as an oncogene in glioma and could be explored as a potential prognostic biomarker and therapeutic target for glioma.

Keywords: KLF2; SNHG3; glioma; p21.

MeSH terms

  • Apoptosis / genetics
  • Brain Neoplasms / genetics
  • Brain Neoplasms / mortality
  • Brain Neoplasms / pathology*
  • Cell Cycle Checkpoints / genetics
  • Cell Line, Tumor
  • Cyclin-Dependent Kinase Inhibitor p21 / genetics*
  • Cyclin-Dependent Kinase Inhibitor p21 / metabolism
  • Enhancer of Zeste Homolog 2 Protein / genetics
  • Enhancer of Zeste Homolog 2 Protein / metabolism
  • Epigenesis, Genetic
  • Female
  • Gene Expression Regulation, Neoplastic
  • Glioma / genetics
  • Glioma / mortality
  • Glioma / pathology*
  • Humans
  • Kruppel-Like Transcription Factors / genetics*
  • Kruppel-Like Transcription Factors / metabolism
  • Male
  • Middle Aged
  • Prognosis
  • Promoter Regions, Genetic
  • RNA, Long Noncoding / genetics*


  • CDKN1A protein, human
  • Cyclin-Dependent Kinase Inhibitor p21
  • KLF2 protein, human
  • Kruppel-Like Transcription Factors
  • RNA, Long Noncoding
  • long non-coding RNA SNHG5, human
  • EZH2 protein, human
  • Enhancer of Zeste Homolog 2 Protein