Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jan;49(1):83-95.
doi: 10.1007/s10803-018-3697-4.

Physical Health in Children With Neurodevelopmental Disorders

Affiliations
Free PMC article

Physical Health in Children With Neurodevelopmental Disorders

Setareh Alabaf et al. J Autism Dev Disord. .
Free PMC article

Erratum in

Abstract

With increasing numbers of children being diagnosed with neurodevelopmental disorders (NDDs) attention has been drawn to these children's physical health. We aimed to identify the prevalence of defined physical problems (epilepsy, migraine, asthma, cancer, diabetes, psoriasis, lactose intolerance, celiac disease, diarrhea, constipation, daytime enuresis, encopresis) in a nationwide population of 9- and 12-year-old twins subdivided into those with and without indications of NDDs. Parents of 28,058 twins participated in a well-validated telephone interview regarding their children's mental health and answered questions about their physical problems. The results indicate a high rate of physical problems in children with NDDs, particularly in those with indications of the presence of combinations of several NDDs.

Keywords: Attention-deficit/hyperactivity disorder (ADHD); Autism spectrum disorder (ASD); Learning disorder (LD); Neurodevelopmental disorders; Physical health; Twins.

Conflict of interest statement

Competing interest

The authors declare that they have no conflicts of interest.

Ethical approval

The CATSS 9/12 study is based on voluntary, informed consent participation and has ethical approval from the Karolinska Institute Ethical Review Board: Dnr 03-672 and 2010/507-31/1.

Figures

Fig. 1
Fig. 1
Flowchart of the study groups. In the present study, A-TAC high cut-offs were used as clinical proxies for ASD, ADHD and LD, which are included in the NDD group. The comparison group included only children who did not fulfill the low cut-off of any NDD. A-TAC autism-tics, ADHD and other comorbidities, NDD neurodevelopmental disorders, ASD autism spectrum disorder, ADHD attention-deficit/ hyperactivity disorder; LD learning disorder
Fig. 2
Fig. 2
The figures show the prevalence of epilepsy (a), migraine (b), asthma (c), cancer (d), diabetes (e) and psoriasis (f) in our study groups and the statistical comparison to the comparison group consisting of twins who screened negative for neurodevelopmental disorders. Statistical significance is marked by stars, where p < 0.05 is represented by *, p < 0.01 by ** and p < 0.001 by ***. NDDs neurodevelopmental disorders, ASD autism spectrum disorder, ADHD attention-deficit/hyperactivity disorder and LD learning disorder
Fig. 3
Fig. 3
The figures show the prevalence of lactose intolerance (a), celiac disease (b), diarrhea (c), constipation (d), daytime enuresis (e) and encopresis (f) in our study groups and the statistical comparison to the comparison group consisting of twins who screened negative for neurodevelopmental disorders. Statistical significance is marked by stars, where p < 0.05 is represented by *, p < 0.01 by ** and p < 0.001 by ***. NDDs neurodevelopmental disorders, ASD autism spectrum disorder, ADHD attention-deficit/hyperactivity disorder and LD learning disorder

Similar articles

See all similar articles

Cited by 4 articles

References

    1. AmericanPsychiatricAssociation . Diagnostic and statistical manual of mental disorder. 5. Philadelphia: American Psychiatric Association; 2013.
    1. Amiet C, Gourfinkel-An I, Bouzamondo A, Tordjman S, Baulac M, Lechat P, Cohen D. Epilepsy in autism is associated with intellectual disability and gender: Evidence from a meta-analysis. Biological Psychiatry. 2008;64(7):577–582. - PubMed
    1. Anckarsater H. Beyond categorical diagnostics in psychiatry: Scientific and medicolegal implications. International Journal of Law and Psychiatry. 2010;33(2):59–65. - PubMed
    1. Anckarsater H, Lundstrom S, Kollberg L, Kerekes N, Palm C, Carlstrom E, Lichtenstein P. The child and adolescent twin study in Sweden (CATSS) Twin Research and Human Genetics. 2011;14(6):495–508. - PubMed
    1. Anderson FS, Kunin-Batson AS. Neurocognitive late effects of chemotherapy in children: The past 10years of research on brain structure and function. Pediatric Blood and Cancer. 2009;52(2):159–164. - PubMed

Publication types

LinkOut - more resources

Feedback