Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross-kingdom communication

Rodrigo P Soares; Patrícia Xander; Adriana Oliveira Costa; Antonio Marcilla; Armando Menezes-Neto; Hernando Del Portillo; Kenneth Witwer; Marca Wauben; Esther Nolte-T Hoen; Martin Olivier; Miriã Ferreira Criado; Luis Lamberti P da Silva; Munira Muhammad Abdel Baqui; Sergio Schenkman; Walter Colli; Maria Julia Manso Alves; Karen Spadari Ferreira; Rosana Puccia; Peter Nejsum; Kristian Riesbeck; Allan Stensballe; Eline Palm Hansen; Lorena Martin Jaular; Reidun Øvstebø; Laura de la Canal; Paolo Bergese; Vera Pereira-Chioccola; Michael W Pfaffl; Joëlle Fritz; Yong Song Gho; Ana Claudia Torrecilhas

doi:10.1080/20013078.2017.1407213

Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross-kingdom communication

J Extracell Vesicles. 2017 Nov 26;6(1):1407213. doi: 10.1080/20013078.2017.1407213. eCollection 2017.

Authors

Rodrigo P Soares¹, Patrícia Xander², Adriana Oliveira Costa³, Antonio Marcilla^{4

5}, Armando Menezes-Neto¹, Hernando Del Portillo^{6

7}, Kenneth Witwer⁸, Marca Wauben⁹, Esther Nolte-T Hoen⁹, Martin Olivier¹⁰, Miriã Ferreira Criado¹¹, Luis Lamberti P da Silva¹¹, Munira Muhammad Abdel Baqui¹¹, Sergio Schenkman¹², Walter Colli¹³, Maria Julia Manso Alves¹³, Karen Spadari Ferreira², Rosana Puccia¹², Peter Nejsum¹⁴, Kristian Riesbeck¹⁵, Allan Stensballe¹⁶, Eline Palm Hansen¹⁷, Lorena Martin Jaular¹⁸, Reidun Øvstebø¹⁹, Laura de la Canal²⁰, Paolo Bergese²¹, Vera Pereira-Chioccola²², Michael W Pfaffl²³, Joëlle Fritz²⁴, Yong Song Gho²⁵, Ana Claudia Torrecilhas²

Affiliations

¹ Centro de Pesquisas René Rachou/FIOCRUZ, Belo Horizonte.
² Laboratório de Imunologia Celular e Bioquímica de Fungos e Protozoários, Departamento de Ciências Farmacêuticas, UNIFESP, São Paulo, Brazil.
³ Departamento de Analises Clinicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
⁴ Área de Parasitología, Departamento de Farmacia y Tecnología Farmacéutica y Parasitología, Universitat de València, Valencia, Spain.
⁵ Joint Research Unit on Endocrinology, Nutrition and Clinical Dietetics, Health Research Institute-La Fe, Universitat de València, Valencia, Spain.
⁶ ICREA, Barcelona, Spain & ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
⁷ Institut d'Investigació Germans Trias i Pujol (IGTP), Badalona, Spain.
⁸ Department of Molecular and Comparative Pathobiology, and Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
⁹ Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
¹⁰ Department of Microbiology and Immunology, McGill University, Montréal, Canada.
¹¹ Department of Cell and Molecular Biology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
¹² Departamento de Microbiologia, Imunologia e Parasitologia, UNIFESP, São Paulo, Brazil.
¹³ Departamento de Bioquímica, IQ, USP, São Paulo, Brazil.
¹⁴ Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.
¹⁵ Clinical Microbiology, Department of Translational Medicine, Lund University, Malmö, Sweden.
¹⁶ Aalborg University, Aalborg, Denmark.
¹⁷ Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
¹⁸ Institut Curie, PSL Research University INSERM U932, Paris, France.
¹⁹ Head of the Blood Cell Research Group, Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.
²⁰ University of Mar del Plata, Mar del Plata, Argentina.
²¹ Department of Molecular and Translational Medicine, INSTM, CSGI University of Brescia, Brescia, Italy.
²² Adolfo Lutz Institute, São Paulo, Brazil.
²³ Department of Animal Physiology & Immunology, School of Life Science, Technical University of Munich, Freising Weihenstephan, Germany.
²⁴ Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Luxembourg.
²⁵ Department of Life Sciences, POSTECH (Pohang University of Science and Technology), Pohang, South Korea.

Abstract

In the past years, extracellular vesicles (EVs) have become an important field of research since EVs have been found to play a central role in biological processes. In pathogens, EVs are involved in several events during the host-pathogen interaction, including invasion, immunomodulation, and pathology as well as parasite-parasite communication. In this report, we summarised the role of EVs in infections caused by viruses, bacteria, fungi, protozoa, and helminths based on the talks and discussions carried out during the International Society for Extracellular Vesicles (ISEV) workshop held in São Paulo (November, 2016), Brazil, entitled Cross-organism Communication by Extracellular Vesicles: Hosts, Microbes and Parasites.

Keywords: Extracellular vesicles; cell communication; infectious diseases; isolation; pathogens.

Grants and funding

The event was also partially supported by grants from the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP 2016/12111-0) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). A.C.T is currently supported by FAPESP grant 2016/01917-3. R.P.S. is currently supported by FAPEMIG grant PPM-X 00102-16. P. X. is currently supported by FAPESP grant 2016/17245-4. A. M. is currently supported by Conselleria d’Educació, Cultura i Esports, Generalitat Valenciana (Valencia, Spain) grant PROMETEO/2016/156.