Effects of Gamisoyo-San Decoction, a Traditional Chinese Medicine, on Gastrointestinal Motility

Digestion. 2018;98(4):231-237. doi: 10.1159/000489455. Epub 2018 Jul 25.

Abstract

Background: Gamisoyo-San decoction (GSS), a traditional Chinese medicine, has been used to treat various gastrointestinal (GI) symptoms and diseases such as functional dyspepsia. The purpose of this study was to investigate the effect of GSS on GI motility functions in mice.

Methods: Percent intestinal transit rate (ITR%) and gastric emptying (GE) values were measured using Evans Blue and phenol red, respectively, in normal mice and in mice with experimentally induced GI motility dysfunction (GMD).

Results: In normal mice, GSS (0.01-1 g/kg) induced higher GE values than non-treated controls. Also, GSS could increase GE in loperamide-induced and cisplatin-induced GE delay models. In addition, GSS increased ITR% in a dose-dependent manner. Loperamide decreased ITR% and GSS recovered this loperamide-induced decrease in ITR%. To examine the effect of GSS on GMD, we used acetic acid (AA)-induced and streptozotocin (STZ)-induced mouse GMD models. The AA mouse model showed a significant decrease in ITR%. However, intragastric treatment with GSS significantly recovered this inhibition. Furthermore, STZ-induced diabetic mice showed a significant reduction in ITR%, which was also significantly inhibited by GSS.

Conclusion: These results demonstrate that GSS can modulate bowel activity and that it could be used as a gastroprokinetic agent in the treatment of GI motility diseases.

Keywords: Gamisoyo-San decoction; Gastric emptying; Gastrointestinal motility; Gastroprokinetic agents; Intestinal transit rate.

MeSH terms

  • Acetic Acid / toxicity
  • Animals
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Drugs, Chinese Herbal / pharmacology*
  • Drugs, Chinese Herbal / therapeutic use
  • Gastrointestinal Agents / pharmacology*
  • Gastrointestinal Agents / therapeutic use
  • Gastrointestinal Diseases / chemically induced
  • Gastrointestinal Diseases / drug therapy*
  • Gastrointestinal Diseases / physiopathology
  • Gastrointestinal Transit / drug effects*
  • Humans
  • Male
  • Mice
  • Mice, Inbred ICR
  • Streptozocin / toxicity
  • Treatment Outcome

Substances

  • Drugs, Chinese Herbal
  • Gastrointestinal Agents
  • gamisoyo-san
  • Streptozocin
  • Acetic Acid