Challenges and recent progress in drug discovery for tropical diseases

Nature. 2018 Jul;559(7715):498-506. doi: 10.1038/s41586-018-0327-4. Epub 2018 Jul 25.


Infectious tropical diseases have a huge effect in terms of mortality and morbidity, and impose a heavy economic burden on affected countries. These diseases predominantly affect the world's poorest people. Currently available drugs are inadequate for the majority of these diseases, and there is an urgent need for new treatments. This Review discusses some of the challenges involved in developing new drugs to treat these diseases and highlights recent progress. While there have been notable successes, there is still a long way to go.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Coinfection
  • Drug Discovery / trends*
  • Humans
  • Infections / drug therapy*
  • Infections / microbiology
  • Infections / parasitology
  • Infections / virology
  • Tropical Climate*
  • Tropical Medicine / trends*