Early and mid-term results of isolated aortic valve neocuspidization in patients with aortic stenosis

Gen Thorac Cardiovasc Surg. 2018 Nov;66(11):648-652. doi: 10.1007/s11748-018-0976-0. Epub 2018 Jul 25.


Objectives: This study aimed to elucidate the surgical outcome of aortic valve neocuspidization (AVNeo) in patients with aortic stenosis (AS).

Methods: From December 2010 to June 2017, we performed AVNeo for aortic valve pathologies in 144 patients. Of them, we evaluated 57 patients with AS who underwent AVNeo. Their mean age was 77.5 ± 8.8 years. Fifty-five patients had AS from degenerative changes, 1 from pericardium endocarditis, and 1 from prosthetic valve endocarditis. Forty patients had a tricuspid aortic valve, 1 had a unicuspid valve, 14 had a bicuspid valve, 1 had a quadricuspid valve, and 1 had postoperative aortic valve replacement (AVR). Preoperative echocardiography revealed an average peak pressure gradient of 89 ± 32.9 mmHg and a mean pressure gradient of 52 ± 18.8 mmHg. The surgical procedure complies with the 3 cuspid suturing to the aortic annulus with the glutaraldehyde-treated pericardium.

Results: There were no conversions to AVR. There were 2 noncardiac-related deaths owing to liver failure and sepsis. Postoperative echocardiography showed an average peak pressure gradient of 22 ± 10.7 mmHg 1 week after the procedure and 19.2 ± 9.7 mmHg 20 months after the procedure. Two patients underwent reoperation owing to infective endocarditis and recurrent aortic regurgitation. The mean follow-up period was 30.4 ± 20.8 months. The freedom from reoperation rates was 98.1 and 95.3% at 12 and 81 months of follow-up, respectively.

Conclusions: AVNeo is suitable for patients with AS considering its early and mid-term outcomes. Verification of long-term outcomes and reliability is necessary.

Keywords: Aortic stenosis; Aortic valve neocuspidization; Glutaraldehyde-treated pericardium.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aortic Valve / diagnostic imaging
  • Aortic Valve / physiopathology
  • Aortic Valve / surgery*
  • Aortic Valve Insufficiency / diagnostic imaging
  • Aortic Valve Insufficiency / physiopathology
  • Aortic Valve Insufficiency / surgery*
  • Aortic Valve Stenosis / diagnostic imaging
  • Aortic Valve Stenosis / physiopathology
  • Aortic Valve Stenosis / surgery*
  • Cardiac Surgical Procedures
  • Echocardiography
  • Female
  • Follow-Up Studies
  • Heart Valve Prosthesis
  • Hemodynamics
  • Humans
  • Male
  • Middle Aged
  • Mitral Valve / physiology
  • Pericardium / transplantation*
  • Postoperative Period
  • Reoperation
  • Reproducibility of Results
  • Retrospective Studies
  • Time Factors