Sequelae of tick-borne encephalitis in retrospective analysis of 1072 patients

Epidemiol Infect. 2018 Oct;146(13):1663-1670. doi: 10.1017/S0950268818002005. Epub 2018 Jul 26.


Tick-borne encephalitis (TBE) is an emerging vector-borne disease in Europe. The aim of the study was to evaluate sequelae and to analyse the potential risk factors predisposing to sequelae development. We performed a retrospective analysis of medical records of 1072 patients who received a 1-month follow-up appointment after hospital discharge. Medical data, such as patients' age, gender, place of living, subjective complaints, neurological and psychiatric sequelae were evaluated twice: at the moment of discharge and at follow-up visits 1 month after discharge. We observed that sequelae may affect 20.6% of TBE patients. Subjective sequelae were more frequent than subjective complaints during the hospitalisation (P < 0.001), while objective neurological symptoms during the hospitalisation were more pronounced than neurological sequelae (P < 0.001). Patients with meningoencephalomyelitis were predisposed to neurological complications, while subjective symptoms were more common in meningoencephalitis. Independent risk factors for sequelae development were: age and cerebrospinal fluid (CSF) protein concentration. The risk of late neurological complications persisting was increased in patients with higher CSF protein concentration. Based on the results of our study we concluded that, there is a need for a better vaccination program, which would prevent the development of sequelae.

Keywords: Sequelae; TBE; tick; vaccination.

MeSH terms

  • Adult
  • Encephalitis Viruses, Tick-Borne / physiology*
  • Encephalitis, Tick-Borne / complications*
  • Female
  • Humans
  • Male
  • Mental Disorders / epidemiology*
  • Mental Disorders / virology
  • Middle Aged
  • Nervous System Diseases / epidemiology*
  • Nervous System Diseases / virology
  • Poland / epidemiology
  • Prevalence
  • Retrospective Studies
  • Risk Factors