Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jan:193:91-98.
doi: 10.1016/j.pharmthera.2018.07.006. Epub 2018 Jul 23.

Bioactive lysolipids in cancer and angiogenesis

Yu Hisano  1 , Timothy Hla  2
Affiliations
Free PMC article
Review

Bioactive lysolipids in cancer and angiogenesis

Yu Hisano et al. Pharmacol Ther. 2019 Jan.
Free PMC article

Abstract

While normal angiogenesis is critical for development and tissue growth, pathological angiogenesis is important for the growth and spread of cancers by supplying nutrients and oxygen as well as providing a conduit for distant metastasis. The interaction among extracellular matrix molecules, tumor cells, endothelial cells, fibroblasts, and immune cells is critical in pathological angiogenesis, in which various angiogenic growth factors, chemokines, and lipid mediators produced from these cells as well as hypoxic microenvironment promote angiogenesis by regulating expression and/or activity of various related genes. Sphingosine 1-phosphate and lysophosphatidic acid, bioactive lipid mediators which act via specific G protein-coupled receptors, play critical roles in angiogenesis. In addition, other lipid mediators including prostaglandin E2, lipoxin, and resolvins are produced in a stimulus-dependent manner and have pro- or anti-angiogenic effects, presumably through their specific GPCRs. Dysregulated lipid mediator signaling pathways are observed in the contxt of some tumors. This review will focus on LPA and S1P, two bioactive lipid mediators in their regulation of angiogenesis and cell migration that are critical for tumor growth and spread.

Keywords: Angiogenesis; Cancer; Lipid mediator; Migration; Sphingosine 1-phosphate.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest

The authors declare that there are no conflicts of interest.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Alfranca A, López-Oliva JM, Genís L, López-Maderuelo D, Mirones I, Salvado D, et al. (2008). PGE2 induces angiogenesis via MT1-MMP–mediated activation of the TGFβ/Alk5 signaling pathway. Blood 112(4), 1120 10.1182/blood-2007-09-112268. - DOI - PubMed
    1. Amano H, Hayashi I, Endo H, Kitasato H, Yamashina S, Maruyama T, et al. (2003). Host prostaglandin EbsubN2b/subN-EP3 signaling regulates tumor-associated angio-genesis and tumor growth. The Journal of Experimental Medicine 197(2), 221–232. - PMC - PubMed
    1. Amano H, Ito Y, Suzuki T, Kato S, Matsui Y, Ogawa F, et al. (2009). Roles of a pros-taglandin E-type receptor, EP3, in upregulation of matrix metalloproteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasis. Cancer Science 100(12), 2318–2324. - PubMed
    1. Anelli V, Gault CR, Cheng AB, & Obeid LM (2008). Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and2. The Journal of Biological Chemistry 283(6), 3365–3375. - PubMed
    1. Arikawa K, Takuwa N, Yamaguchi H, Sugimoto N, Kitayama J, Nagawa H, et al. (2003). Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity. The Journal of Biological Chemistry 278(35), 32841–32851. - PubMed

Publication types