Osimertinib Depletes EGFR T790M in the Spinal Fluid of Patients with Carcinomatous Meningitis of Lung Adenocarcinoma Harboring De Novo EGFR T790M

J Thorac Oncol. 2018 Aug;13(8):e140-e142. doi: 10.1016/j.jtho.2018.03.016.
No abstract available

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylamides / administration & dosage*
  • Adenocarcinoma of Lung / cerebrospinal fluid*
  • Adenocarcinoma of Lung / genetics
  • Adenocarcinoma of Lung / pathology
  • Adenocarcinoma of Lung / therapy
  • Aged
  • Aniline Compounds / administration & dosage*
  • Brain Neoplasms / cerebrospinal fluid
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / secondary*
  • Chemoradiotherapy
  • ErbB Receptors / cerebrospinal fluid
  • ErbB Receptors / genetics
  • Female
  • Humans
  • Lung Neoplasms / cerebrospinal fluid*
  • Lung Neoplasms / genetics
  • Lung Neoplasms / pathology
  • Lung Neoplasms / therapy
  • Meningeal Carcinomatosis / cerebrospinal fluid
  • Meningeal Carcinomatosis / drug therapy*
  • Meningeal Carcinomatosis / pathology
  • Meningeal Carcinomatosis / secondary*

Substances

  • Acrylamides
  • Aniline Compounds
  • osimertinib
  • EGFR protein, human
  • ErbB Receptors