A review of the multifunctionality of angiopoietin-like 4 in eye disease

Biosci Rep. 2018 Sep 13;38(5):BSR20180557. doi: 10.1042/BSR20180557. Print 2018 Oct 31.

Abstract

Angiopoietin-like protein 4 (ANGPTL4) is a multifunctional cytokine regulating vascular permeability, angiogenesis, and inflammation. Dysregulations in these responses contribute to the pathogenesis of ischemic retinopathies such as diabetic retinopathy (DR), age-related macular degeneration (AMD), retinal vein occlusion, and sickle cell retinopathy (SCR). However, the role of ANGPTL4 in these diseases remains controversial. Here, we summarize the functional mechanisms of ANGPTL4 in several diseases. We highlight original studies that provide detailed data about the mechanisms of action for ANGPTL4, its applications as a diagnostic or prognostic biomarker, and its use as a potential therapeutic target. Taken together, the discussions in this review will help us gain a better understanding of the molecular mechanisms by which ANGPTL4 functions in eye disease and will provide directions for future research.

Keywords: ANGPTL4; angiogenesis; inflammation; ocular diseases; vascular permeability.

Publication types

  • Review

MeSH terms

  • Angiopoietin-Like Protein 4 / chemistry
  • Angiopoietin-Like Protein 4 / physiology*
  • Biomarkers / analysis
  • Biomarkers / metabolism
  • Diabetic Retinopathy / metabolism
  • Eye Diseases / metabolism*
  • Eye Diseases / therapy
  • Humans
  • Inflammation / metabolism
  • Lipid Metabolism
  • Macular Degeneration / metabolism
  • Melanoma / metabolism
  • Molecular Targeted Therapy
  • Neovascularization, Pathologic / metabolism
  • Neovascularization, Physiologic
  • Uveal Neoplasms / metabolism

Substances

  • ANGPTL4 protein, human
  • Angiopoietin-Like Protein 4
  • Biomarkers

Supplementary concepts

  • Uveal melanoma