Pricing of HPV vaccines in European tender-based settings

Eur J Health Econ. 2019 Mar;20(2):271-280. doi: 10.1007/s10198-018-0996-9. Epub 2018 Jul 26.


Background: Vaccine price is one of the most influential parameters in economic evaluations of HPV vaccination programmes. Vaccine tendering is a cost-containment method widely used by national or regional health authorities, but information on tender-based HPV vaccine prices is scarce.

Methods: Procurement notices and awards for the HPV vaccines, published from January 2007 until January 2018, were systematically retrieved from the online platform for public procurement in Europe. Information was collected from national or regional tenders organized for publicly funded preadolescent vaccination programmes against HPV. The influence of variables on the vaccine price was estimated by means of a mixed-effects model.

Findings: Prices were collected from 178 procurements announced in 15 European countries. The average price per dose for the first-generation HPV vaccines decreased from €101.8 (95% CI 91.3-114) in 2007 to €28.4 (22.6-33.5) in 2017, whereas the average dose price of the 9-valent vaccine in 2016-2017 was €49.1 (38.0-66.8). Unit prices were, respectively, €7.5 (4.4-10.6) and €34.4 (27.4-41.4) higher for the 4-valent and 9-valent vaccines than for the 2-valent vaccine. Contract volume and duration, level of procurement (region or country), per capita GDP and number of offers received had a significant effect on vaccine price.

Interpretation: HPV vaccine procurement is widely used across Europe. The fourfold decrease in the average tender-based prices compared to list prices confirms the potential of tendering as an efficient cost-containment strategy, thereby expanding the indications for cost-effective HPV vaccination to previously ineligible target groups.

Keywords: Europe; HPV; Price; Procurement; Tender; Vaccine.

Publication types

  • Comparative Study

MeSH terms

  • Commerce / statistics & numerical data
  • Cost Control / economics*
  • Cost Control / methods
  • Cost-Benefit Analysis
  • Databases, Factual
  • Drug Costs / statistics & numerical data*
  • Drug Utilization
  • Europe
  • Female
  • Humans
  • Immunization Programs
  • Papillomavirus Vaccines / economics*
  • Uterine Cervical Neoplasms / prevention & control


  • Papillomavirus Vaccines