Individualized Treatment for Infantile Hemangioma

J Craniofac Surg. 2018 Oct;29(7):1876-1879. doi: 10.1097/SCS.0000000000004745.


Infantile hemangioma can grow dramatically or typically locate on the face, which may lead to functional impairment, cosmetically disfiguring and exhibiting complications such as ulceration, bleeding, or infection. Early intervention is necessary. In this study, the authors chose individual treatment for different patients. From January 2012 to December 2016, 185 patients with hemangioma were enrolled into this study. Lesion area ranged from 0.5 cm × 0.5 cm to 9 cm × 12 cm. The initial treatment age ranged from 1 to 7 months with an average age of 3.9 months. Thirty-five children achieved the treatment of Intralesional Compound Betamethasone, 134 children achieved the treatment of oral propranolol, and 16 children achieved the treatment of topical carteolol. In the follow-up, the treatment could be repeated or switched to oral propranolol if the tumor tended to grow again. At the end of follow-up, 89% of the patients' tumors shrinked or involuted completely, 5 patients switched to oral propranolol. The adverse effects included soft tissue atrophy, moon face, diarrhea, heart rate reduction, and liver enzyme abnormalities. All of the patients recovered in a short period. Early treatment for hemangioma can achieve good results and avoid functional impairment. For different patients, the authors suggest individualized treatment according to the tumors' size and location.

MeSH terms

  • Administration, Cutaneous
  • Administration, Oral
  • Betamethasone / administration & dosage
  • Betamethasone / therapeutic use*
  • Carteolol / administration & dosage
  • Carteolol / therapeutic use*
  • Female
  • Glucocorticoids / administration & dosage
  • Glucocorticoids / therapeutic use*
  • Hemangioma, Capillary / drug therapy*
  • Humans
  • Infant
  • Injections, Intralesional
  • Male
  • Neoplastic Syndromes, Hereditary / drug therapy*
  • Propranolol / administration & dosage
  • Propranolol / therapeutic use*
  • Treatment Outcome
  • Vasodilator Agents / administration & dosage
  • Vasodilator Agents / therapeutic use*


  • Glucocorticoids
  • Vasodilator Agents
  • Carteolol
  • Betamethasone
  • Propranolol

Supplementary concepts

  • Hemangioma, capillary infantile