High-throughput determination of RNA structures

Nat Rev Genet. 2018 Oct;19(10):615-634. doi: 10.1038/s41576-018-0034-x.


RNA performs and regulates a diverse range of cellular processes, with new functional roles being uncovered at a rapid pace. Interest is growing in how these functions are linked to RNA structures that form in the complex cellular environment. A growing suite of technologies that use advances in RNA structural probes, high-throughput sequencing and new computational approaches to interrogate RNA structure at unprecedented throughput are beginning to provide insights into RNA structures at new spatial, temporal and cellular scales.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Computational Biology / methods*
  • High-Throughput Nucleotide Sequencing / methods*
  • Humans
  • Nucleic Acid Conformation*
  • RNA* / chemistry
  • RNA* / genetics
  • RNA* / metabolism
  • Sequence Analysis, RNA / methods*


  • RNA