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Review
. 2018 Oct;75(20):3715-3740.
doi: 10.1007/s00018-018-2886-9. Epub 2018 Jul 27.

Memory Corticalization Triggered by REM Sleep: Mechanisms of Cellular and Systems Consolidation

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Review

Memory Corticalization Triggered by REM Sleep: Mechanisms of Cellular and Systems Consolidation

Daniel G Almeida-Filho et al. Cell Mol Life Sci. .

Abstract

Once viewed as a passive physiological state, sleep is a heterogeneous and complex sequence of brain states with essential effects on synaptic plasticity and neuronal functioning. Rapid-eye-movement (REM) sleep has been shown to promote calcium-dependent plasticity in principal neurons of the cerebral cortex, both during memory consolidation in adults and during post-natal development. This article reviews the plasticity mechanisms triggered by REM sleep, with a focus on the emerging role of kinases and immediate-early genes for the progressive corticalization of hippocampus-dependent memories. The body of evidence suggests that memory corticalization triggered by REM sleep is a systemic phenomenon with cellular and molecular causes.

Keywords: Cortical engagement; Long-term memory; Offline consolidation; Plasticity; Trace propagation.

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