Global HBV burden: guesstimates and facts

Hepatol Int. 2018 Jul;12(4):315-329. doi: 10.1007/s12072-018-9884-8. Epub 2018 Jul 27.


Chronic hepatitis B virus infection (HBV) continues to pose a serious global health threat in many areas of the world, particularly in sub-Saharan Africa, the Western Pacific Region and areas of Eastern Europe. Endemicity is heterogeneous within and across regions owing to variable implementation of childhood and birth-dose vaccination programs, inconsistent screening of blood products, injection drug use, and poor education initiatives. This review aims to provide comprehensive up-to-date estimates of global seroprevalence of chronic HBV across six World Health Organization (WHO) regions, noting patterns of change over time and highlighting potential region-specific barriers to the diagnosis and elimination of HBV.

Keywords: Chronic liver disease; Global prevalence; Hepatitis B virus; Seroprevalence; Viral hepatitis.

Publication types

  • Review

MeSH terms

  • Global Health
  • Hepatitis B virus
  • Hepatitis B, Chronic / epidemiology*
  • Hepatitis B, Chronic / virology
  • Humans
  • Prevalence