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, 18 (1), 184

Retinal Vascular Flow and Choroidal Thickness in Eyes With Early Age-Related Macular Degeneration With Reticular Pseudodrusen

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Retinal Vascular Flow and Choroidal Thickness in Eyes With Early Age-Related Macular Degeneration With Reticular Pseudodrusen

So Min Ahn et al. BMC Ophthalmol.

Abstract

Background: To investigate the characteristics of retinal vessels and retinal thickness in eyes with early age-related macular degeneration (AMD) with or without reticular pseudodrusen.

Methods: We retrospectively evaluated the clinical history and optical coherence tomography (OCT) and OCT angiography images of consecutive patients with early AMD. We calculated the retinal vessel densities of the superficial and deep capillary plexus with the ImageJ software (National Institutes of Health, Bethesda, MD, USA) and investigated the relationship with mean retinal thickness and subfoveal choroidal thickness.

Results: We included 135 early AMD eyes and classified 60 of them into a reticular pseudodrusen group and 75 into a non-reticular pseudodrusen group. The vascular densities of the superficial and deep capillary plexus in the reticular pseudodrusen group (32.35% ± 3.67 and 26.71% ± 2.88%) were not different from those of the non-reticular pseudodrusen group (33.18% ± 2.2% and % 27.43 ± 1.79%; P = 0.546 and P = 0.318, respectively). The retinal thickness of the reticular pseudodrusen group (287.31 μm ± 24.36 μm) did not differ from that of the non-reticular pseudodrusen group (294.27 μm ± 20.71 μm; P = 0.493), while subfoveal choroidal thickness in the reticular pseudodrusen group (158.13 μm ± 42.53 μm) was lower than that in the non-reticular pseudodrusen group (237.89 μm ± 60.94 μm; P < 0.001). Multivariate analysis revealed that lower vascular density of the superficial capillary plexus and subfoveal choroidal thickness were associated with retinal thinning in reticular pseudodrusen group (P = 0.003 and P = 0.036) and older age was associated with retinal thickness in the non-reticular pseudodrusen group (P = 0.005).

Conclusions: Retinal thinning in early AMD patients with reticular pseudodrusen was accompanied by choroidal and retinal vascular loss, which suggests a possible linkage of retinal thinning with vascular alterations.

Keywords: Early age-related macular degeneration; Optical coherence tomography angiography; Reticular pseudodrusen; Retinal atrophy.

Conflict of interest statement

Ethics approval and consent to participate

This study was approved by the institutional review board of Korea University Medical Center in Seoul, Korea. All data collection and analysis efforts were conducted in accordance with the tenets of the Declaration of Helsinki.

Consent for publication

Not applicable.

Competing interests

J. Oh is a consultant of Topcon Corporation. The remaining authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Scatter plots of retinal thickness and its associations with age, subfoveal choroidal thickness, and vascular densities. In the reticular pseudodrusen group (a-d), retinal thickness was negatively associated with age and the vascular densities of the superficial capillary plexus and deep capillary plexus and was positively associated with subfoveal choroidal thickness. In the non- reticular pseudodrusen group (e-h), retinal thickness was negatively associated with age and positively associated with subfoveal choroidal thickness and had no relationship with the vascular densities of the superficial capillary plexus and deep capillary plexus
Fig. 2
Fig. 2
Representative cases of patients with early AMD and reticular pseudodrusen. OCT and OCTA images of a 71-year-old female patient (a-d) and a 75-year-old male patient (e-h) with early AMD and reticular pseudodrusen. a Line scan shows multiple subretinal drusenoid deposits with 193 μm subfoveal choroidal thickness. b ETDRS grid shows normal range retinal thickness. c and d OCTA shows relatively preserved superficial capillary plexuses and deep capillary plexuses. e Line scan shows multiple subretinal drusenoid deposits with 65 μm subfoveal choroidal thickness. f ETDRS grid shows decreased retinal thickness. g and h OCTA shows relatively decreased vascular densities of the superficial capillary plexus and deep capillary plexus

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