French consensus: Augmentation syndrome in restless legs syndrome

Rev Neurol (Paris). 2018 Sep-Oct;174(7-8):532-539. doi: 10.1016/j.neurol.2018.06.004. Epub 2018 Jul 25.


Augmentation syndrome is one of the most severe complications of RLS. It is characterised by a worsening of treated symptoms; principally an increase in the severity of symptoms and an earlier onset time. Augmentation syndrome occurs primarily with dopaminergic treatments. It is crucial for the patient to be sufficiently well informed to prevent its occurrence and the prescription of too high doses of dopaminergic agonists avoided. In the presence of augmentation syndrome confirmed using the diagnostic criteria, the specialist treating the restless legs syndrome should quickly modify the patient's treatment. In this article, our expert group proposes a practical strategy for the diagnosis, prevention and treatment of augmentation syndrome.

Keywords: Augmentation syndrome; Dopaminergic agonist; Iron deficiency; Restless legs syndrome.

Publication types

  • Review

MeSH terms

  • Consensus
  • Dopamine Agonists / adverse effects
  • Dopamine Agonists / therapeutic use
  • France
  • Humans
  • Iron Deficiencies
  • Restless Legs Syndrome / complications*
  • Restless Legs Syndrome / diagnosis
  • Restless Legs Syndrome / therapy*
  • Syndrome


  • Dopamine Agonists