Effects of leukocyte-platelet-rich fibrin (L-PRF) in different intraoral bone grafting procedures: a systematic review

Int J Oral Maxillofac Surg. 2019 Feb;48(2):250-262. doi: 10.1016/j.ijom.2018.06.003. Epub 2018 Jul 7.


This systematic review aimed to assess the effects of leukocyte-platelet-rich fibrin (L-PRF) on bone regeneration, soft tissue healing, and postoperative complications in patients undergoing ridge preservation, ridge augmentation, and maxillary sinus augmentation procedures. A comprehensive literature search was conducted by two independent reviewers. Only randomized and non-randomized controlled clinical trials were selected. Outcome data were extracted and critically analyzed. A total of 17 articles were included in the qualitative synthesis. The use of L-PRF in extraction sockets was associated with a modest beneficial effect by decreasing alveolar ridge remodeling and postoperative pain when compared to natural healing. In contrast, the use of L-PRF in maxillary sinus augmentation procedures was not associated with more favorable outcomes, and its use in ridge augmentation procedures could not be assessed adequately as it was reported in only one study. No meta-analysis could be conducted due to the heterogeneity of the selected studies. The limited evidence on the effects of L-PRF in intraoral bone grafting procedures highlights the need for further research to fully assess its clinical indications, with an emphasis on the application of standardized protocols for the preparation of this autologous product.

Keywords: alveolar ridge augmentation; growth factors; leukocytes; maxillary sinus; platelet-rich fibrin; sinus floor augmentation; tooth extraction.

Publication types

  • Systematic Review

MeSH terms

  • Alveolar Ridge Augmentation*
  • Bone Regeneration
  • Bone Remodeling
  • Bone Transplantation / methods*
  • Humans
  • Leukocytes*
  • Pain, Postoperative / prevention & control
  • Platelet-Rich Fibrin*
  • Postoperative Complications / prevention & control
  • Sinus Floor Augmentation*
  • Wound Healing