The Improvement of Memory Deficits after Whole-Body Cryotherapy - The First Report

Cryo Letters. May/Jun 2018;39(3):190-195.


Background: Mild Cognitive Impairments (MCI) and dementia are still incurable. The Whole-Body Cryotherapy (WBC) - short, cyclic exposure to extremely low temperatures - has proven anti-inflammatory and anti-oxidative effects. It can also induce hormonal, lipid and neural changes.

Objective: To evaluate the WBC effect on cognitive functioning and blood parameters of MCI patients.

Materials and methods: Participants with MCI undertook 10 WBC sessions. Cognitive functions and depressive symptoms were assessed before the first session, after the last session and 2 weeks later. Whole blood samples were collected.

Results: The cognitive functioning improved after 10 WBC sessions (p<0.05), especially memory processes. WBC caused a significant (p<0.05) increase of NO plasma level, BDNF concentration (p<0.05) and reduction of IL-6 (p<0.05). The moderate relationship between NO and cognitive functioning was noticed after WBC.

Conclusion: The preliminary results of the first study evaluating WBC on memory deficits suggest that WBC may be useful as a supportive therapy of MCI.

Publication types

  • Clinical Trial

MeSH terms

  • Aged
  • Cognitive Dysfunction / blood
  • Cognitive Dysfunction / therapy*
  • Cold Temperature
  • Cryotherapy / methods*
  • Cytokines / blood
  • Female
  • Humans
  • Male


  • Cytokines