Abstract
This Perspective highlights the advances of optical methods for asymmetric reaction discovery. Optical analysis allows for the determination of absolute configuration, enantiomeric excess and reaction yield that is amenable to high-throughput experimentation. Thus, the synthetic organic community is encouraged to incorporate the methods discussed to expedite the development of high-yielding, enantioselective transformations.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Catalysis
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Chromatography, High Pressure Liquid
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Circular Dichroism
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Colorimetry / methods
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High-Throughput Screening Assays
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Structure
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Optical Imaging*
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Organic Chemicals / chemistry
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Particle Size
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Spectrophotometry, Ultraviolet
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Stereoisomerism