Sugar-Sweetened Soft Drinks and Fructose Consumption Are Associated with Hyperuricemia: Cross-Sectional Analysis from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Nutrients. 2018 Jul 27;10(8):981. doi: 10.3390/nu10080981.


The secular trend of hyperuricemia coincides with the substantial increase in the consumption of sugar-sweetened beverages. Our aim was to evaluate the association between the consumption of soft drinks, dietary fructose and unsweetened, non-processed fruit juices with hyperuricemia in a cross-sectional analysis of baseline data (2008⁻2010; n = 7173) of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). The explanatory variables were the consumption of soft drinks, fruit juice, and fructose using a validated semi-quantitative food frequency questionnaire. The outcomes were hyperuricemia and the uric acid concentration in serum. Regression models were tested, and a significance level of 5% was adopted. In men, the daily consumption of a portion of soft drink/day (250 mL) almost doubled the chance of hyperuricemia with a linear trend. In women, the consumption of ≥0.1 to <1.0 soft drink/day was associated with a higher chance of hyperuricemia, but there was no linear trend. High fructose consumption in men and moderate and high consumption in women were associated with hyperuricemia. All categories of soft drinks consumption were linearly associated with increased serum uric acid levels. Our findings suggest that the consumption of soft drinks and dietary fructose is positively associated with a higher chance of hyperuricemia and higher uric acid levels in Brazilian adults.

Keywords: fructose; fruit and vegetable juices; hyperuricemia; sugar-sweetened soft drinks intake; uric acid.

MeSH terms

  • Adult
  • Aged
  • Beverages / adverse effects
  • Brazil
  • Carbonated Beverages / adverse effects*
  • Cross-Sectional Studies
  • Diet / adverse effects*
  • Dietary Sucrose / adverse effects*
  • Dietary Sugars / adverse effects
  • Feeding Behavior
  • Female
  • Fructose / adverse effects*
  • Fruit and Vegetable Juices / adverse effects
  • Humans
  • Hyperuricemia / blood
  • Hyperuricemia / etiology*
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Nutrition Surveys
  • Sweetening Agents / adverse effects*
  • Uric Acid / blood*


  • Dietary Sucrose
  • Dietary Sugars
  • Sweetening Agents
  • Uric Acid
  • Fructose