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Review
. 2018 Jul 28;19(8):2208.
doi: 10.3390/ijms19082208.

Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases

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Free PMC article
Review

Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases

Yen-Chun Koh et al. Int J Mol Sci. .
Free PMC article

Abstract

Macrophages can polarize into two different states (M1 and M2), which play contrasting roles during pathogenesis or tissue damage. M1 polarized macrophages produce pro-inflammatory cytokines and mediators resulting in inflammation, while M2 macrophages have an anti-inflammatory effect. Secretion of appropriate cytokines and chemokines from macrophages can lead to the modification of the microenvironment for bridging innate and adaptive immune responses. Increasing evidence suggests that polarized macrophages are pivotal for disease progression, and the regulation of macrophage polarization may provide a new approach in therapeutic treatment of inflammation-related diseases, including cancer, obesity and metabolic diseases, fibrosis in organs, brain damage and neuron injuries, and colorectal disease. Polarized macrophages affect the microenvironment by secreting cytokines and chemokines while cytokines or mediators that are produced by resident cells or tissues may also influence macrophages behavior. The interplay of macrophages and other cells can affect disease progression, and therefore, understanding the activation of macrophages and the interaction between polarized macrophages and disease progression is imperative prior to taking therapeutic or preventive actions. Manipulation of macrophages can be an entry point for disease improvement, but the mechanism and potential must be understood. In this review, some advanced studies regarding the role of macrophages in different diseases, potential mechanisms involved, and intervention of drugs or phytochemicals, which are effective on macrophage polarization, will be discussed.

Keywords: M1/M2 macrophage; chemoprevention; inflammation; phytochemicals.

Conflict of interest statement

There are no conflicts to declare.

Figures

Figure 1
Figure 1
M1 macrophage polarization mechanisms mentioned in Section 2. Blue circle, inducers; white blocks, genes/proteins involved.
Figure 2
Figure 2
M2 macrophage polarization mechanisms mentioned in Section 2. Blue circle, inducers; white blocks, genes/proteins involved.
Figure 3
Figure 3
Some strategies proposed for intestinal and colorectal diseases amelioration mentioned in Section 3. Blue circle, samples intervened; yellow block, microRNA intervened; white blocks, genes/proteins involved.
Figure 4
Figure 4
Some strategies proposed for brain injuries attenuation and neuron protection mentioned in Section 5. Blue circle, samples intervened; yellow block, microRNA intervened; white blocks, genes/proteins involved.

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