1 Regenerative Medicine Institute (REMEDI) at the Centre for Research in Medical Devices (CÚRAM), Biomedical Sciences, National University of Ireland Galway, Galway, Ireland; School of Medicine, College of Medicine, Nursing, and Health Sciences, National University of Ireland Galway, Galway, Ireland; Department of Anaesthesia, Department of Physiology, and Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON M5G 1X8, Canada.
2 Department of Anaesthesia, Department of Physiology, and Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON M5G 1X8, Canada; Department of Critical Care Medicine, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address: brian.kavanagh@utoronto.ca.