Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system

Nat Chem Biol. 2018 Sep;14(9):841-843. doi: 10.1038/s41589-018-0101-9. Epub 2018 Jul 30.


Genome mining and chemical analyses revealed that rhizosphere bacteria (Paraburkholderia graminis) produce a new type of siderophore, gramibactin, a lipodepsipeptide that efficiently binds iron with a logβ value of 27.6. Complexation-induced proton NMR chemical shifts show that the unusual N-nitrosohydroxylamine (diazeniumdiolate) moieties participate in metal binding. Gramibactin biosynthesis genes are conserved in numerous plant-associated bacteria associated with rice, wheat, and maize, which may utilize iron from the complex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azo Compounds / chemistry*
  • Burkholderiaceae / chemistry*
  • Ligands
  • Potentiometry
  • Siderophores / chemistry*
  • Siderophores / isolation & purification
  • Zea mays / growth & development
  • Zea mays / microbiology


  • Azo Compounds
  • Ligands
  • Siderophores
  • diazeniumdiolate