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. 2018 Aug 14;54(66):9202-9205.
doi: 10.1039/c8cc03907k.

Unveiling Epidithiodiketopiperazine as a Non-Histone Arginine Methyltransferase Inhibitor by Chemical Protein Methylome Analyses

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Unveiling Epidithiodiketopiperazine as a Non-Histone Arginine Methyltransferase Inhibitor by Chemical Protein Methylome Analyses

Yoshihiro Sohtome et al. Chem Commun (Camb). .

Abstract

We present a chemical methylome analysis platform to evaluate the inhibitory activity of small molecules towards poorly characterized protein methyltransferases (PMTs), facsilitating to identify syn-HyPA-ETP-2 as a non-histone arginine methyltransferase inhibitor.

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