Dietary acrylamide intake and the risk of endometrial or ovarian cancers in Japanese women

Cancer Sci. 2018 Oct;109(10):3316-3325. doi: 10.1111/cas.13757. Epub 2018 Aug 24.


A meta-analysis published in 2015 noted a marginally increased risk of endometrial and ovarian cancers in non-smoking women with dietary acrylamide intake, but only a few studies were included, and they were limited to Western countries. The aim of this study was to investigate the association between dietary acrylamide intake and endometrial or ovarian cancer risk in the Japan Public Health Center-based Prospective Study (JPHC Study). In this prospective cohort study, 47 185 participants aged 45-74 years at the follow-up starting point in the JPHC Study were enrolled. Dietary acrylamide intake was assessed using a validated food frequency questionnaire. Cox proportional hazards regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (95%CI). In participants with endometrial and ovarian cancer, the average follow-up periods were 15.5 and 15.6 years, respectively, and 161 and 122 cases of endometrial and ovarian cancer were diagnosed, respectively. Energy-adjusted dietary acrylamide intake was negatively associated with endometrial cancer, but the association disappeared after adjusting for coffee consumption with an adjusted HR for the highest vs lowest tertile of 0.85 (95%CI: 0.54-1.33). No association was observed, however, for ovarian cancer (adjusted HR, 0.77; 95%CI: 0.49-1.23). Furthermore, after stratifying by smoking status, coffee consumption, alcohol consumption, body mass index, and menopause status, no association was observed. Dietary acrylamide intake was not associated with the risk of endometrial or ovarian cancer in Japanese women with a relatively lower dietary intake of acrylamide compared with Western populations.

Keywords: Asia; dietary acrylamide; endometrial cancer; epidemiology; ovarian cancer.

MeSH terms

  • Acrylamide / toxicity*
  • Aged
  • Body Mass Index
  • Coffee
  • Diet Surveys / statistics & numerical data*
  • Endometrial Neoplasms / chemically induced
  • Endometrial Neoplasms / epidemiology*
  • Feeding Behavior
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Japan / epidemiology
  • Middle Aged
  • Ovarian Neoplasms / chemically induced
  • Ovarian Neoplasms / epidemiology*
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Factors


  • Coffee
  • Acrylamide