Emerging mechanisms of dynein transport in the cytoplasm versus the cilium

Biochem Soc Trans. 2018 Aug 20;46(4):967-982. doi: 10.1042/BST20170568. Epub 2018 Jul 31.


Two classes of dynein power long-distance cargo transport in different cellular contexts. Cytoplasmic dynein-1 is responsible for the majority of transport toward microtubule minus ends in the cell interior. Dynein-2, also known as intraflagellar transport dynein, moves cargoes along the axoneme of eukaryotic cilia and flagella. Both dyneins operate as large ATP-driven motor complexes, whose dysfunction is associated with a group of human disorders. But how similar are their mechanisms of action and regulation? To examine this question, this review focuses on recent advances in dynein-1 and -2 research, and probes to what extent the emerging principles of dynein-1 transport could apply to or differ from those of the less well-understood dynein-2 mechanoenzyme.

Keywords: cilia; dynein; intraflagellar transport; kinesin; microtubule.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Axoneme / metabolism
  • Cilia / metabolism*
  • Cytoplasm / metabolism*
  • Dyneins / metabolism*
  • Protein Transport


  • Adenosine Triphosphate
  • Dyneins