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, 14 (9), 1479-1480

Finding a Ribophagy Receptor


Finding a Ribophagy Receptor

Meiyan Jin et al. Autophagy.


Although ribophagy was demonstrated in budding yeast a decade ago, a specific receptor for this process has been unknown. Recently, a study revealed that NUFIP1 (nuclear FMR1 interacting protein 1) functions as a receptor for the selective degradation of ribosomes by starvation-induced autophagy in cultured mammalian cells. In addition to the identification of a selective autophagy receptor, this study suggests a strategy that can be adapted to the identification of additional novel receptor proteins.

Keywords: Autophagy; cargo; receptor; ribosomes; selective autophagy.

Comment on

  • NUFIP1 is a ribosome receptor for starvation-induced ribophagy.
    Wyant GA, Abu-Remaileh M, Frenkel EM, Laqtom NN, Dharamdasani V, Lewis CA, Chan SH, Heinze I, Ori A, Sabatini DM. Wyant GA, et al. Science. 2018 May 18;360(6390):751-758. doi: 10.1126/science.aar2663. Epub 2018 Apr 26. Science. 2018. PMID: 29700228 Free PMC article.

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Grant support

This work was supported by the National Institute of General Medical Sciences [GM053396].