Pulmonary Manifestations of Common Variable Immunodeficiency

J Thorac Imaging. 2018 Nov;33(6):377-383. doi: 10.1097/RTI.0000000000000350.


Common variable immunodeficiency (CVID) is associated with significant chronic lung disease. The purpose of this paper was to describe the clinical, radiologic, and pathologic findings of CVID-associated lung diseases. These include airways' disease, interstitial lung disease, lymphoma, and mucosa-associated lymphoid tissue lymphoma. In addition, a genetic syndrome termed Kabuki syndrome results in CVID-like immune abnormalities. These patients may also present with CVID-associated lung disease. Awareness and precise identification of CVID-associated lung disease may allow for better assessment of prognosis and direction of therapy.

Publication types

  • Review

MeSH terms

  • Chronic Disease
  • Common Variable Immunodeficiency / complications*
  • Common Variable Immunodeficiency / diagnostic imaging*
  • Common Variable Immunodeficiency / immunology
  • Humans
  • Lung / diagnostic imaging
  • Lung / immunology
  • Lung Diseases / complications*
  • Lung Diseases / diagnostic imaging*
  • Lung Diseases / immunology
  • Tomography, X-Ray Computed / methods*