Hyponatremia Induced by Duloxetine: A Case Report

Consult Pharm. 2018 Aug 1;33(8):446-449. doi: 10.4140/TCP.n.2018.446.


Purpose: There are a limited number of case reports in the literature which describe hyponatremia/syndrome of inappropriate antidiuretic hormone (SIADH) induced by duloxetine.

Summary: This case report adds to the literature by describing a patient who developed hyponatremia/SIADH after two doses of duloxetine.

Conclusion: Hyponatremia/SIADH can develop rapidly after initiation of duloxetine. Clinicians should be aware of the potential for this adverse drug reaction, particularly in elderly females.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Duloxetine Hydrochloride / adverse effects*
  • Duloxetine Hydrochloride / therapeutic use
  • Female
  • Humans
  • Hyponatremia / chemically induced*
  • Hyponatremia / diagnosis
  • Inappropriate ADH Syndrome / chemically induced*
  • Inappropriate ADH Syndrome / diagnosis
  • Mood Disorders / complications
  • Mood Disorders / drug therapy
  • Selective Serotonin Reuptake Inhibitors / adverse effects*


  • Serotonin Uptake Inhibitors
  • Duloxetine Hydrochloride