Selected Giant Cell Rich Lesions of the Temporal Bone

Head Neck Pathol. 2018 Sep;12(3):367-377. doi: 10.1007/s12105-018-0906-6. Epub 2018 Aug 1.


Giant cell rich lesions of the temporal bone encompass a wide spectrum of disease that includes infectious, reactive, and neoplastic processes. When dealing with any lesion that can potentially involve bone, it is important to understand both the clinical presentation and to correlate the histologic findings with the radiologic imaging. This review discusses the clinical, the pathologic features including the differential diagnosis, and the treatment of some of the more commonly encountered giant cell rich entities in this region.

Keywords: Chondroblastoma; Giant cell reparative granuloma; Langerhans cell histiocytosis; Sarcoidosis; Temporal bone; Tenosynovial giant cell tumor.

Publication types

  • Review

MeSH terms

  • Diagnosis, Differential
  • Giant Cell Tumor of Bone / diagnosis
  • Giant Cell Tumor of Bone / pathology*
  • Humans
  • Skull Neoplasms / diagnosis
  • Skull Neoplasms / pathology*
  • Temporal Bone / pathology*