Regulation of human mitogen-activated protein kinase 15 (extracellular signal-regulated kinase 7/8) and its functions: A recent update

J Cell Physiol. 2018 Jan;234(1):75-88. doi: 10.1002/jcp.27053. Epub 2018 Aug 2.


Mitogen-activated protein kinase 15 (MAPK15), originally also known as extracellular signal-regulated kinase 7/8, is the most recently identified atypical MAPK and the least studied so far. Examinations of the role of MAPK15 in various cell lines and model systems indicate that MAPK15 participates in a variety of cellular activities such as promoting cell proliferation, cell transformation, and apoptosis; stimulating autophagy; regulating cell division, ciliogenesis, and protein secretion; and maintaining genome stability. As multiple roles of MAPK15 were observed among these studies, therefore, it remains unclear whether MAPK15 acts as a proto-oncogene or tumor suppressor. Here, the recent literature on human MAPK15 and the resulting functions will be discussed.

Keywords: extracellular signal-regulated kinase 7/8 (ERK7/8); mitogen-activated protein kinase 15 (MAPK15); post-translational modifications (PTMs).

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Apoptosis / genetics
  • Autophagy / genetics*
  • Cell Proliferation / genetics*
  • Extracellular Signal-Regulated MAP Kinases / genetics*
  • Gene Expression Regulation / genetics
  • Humans
  • Phosphorylation
  • Protein Transport / genetics
  • Proto-Oncogene Mas
  • Signal Transduction
  • Tumor Suppressor Proteins / genetics*


  • MAS1 protein, human
  • Proto-Oncogene Mas
  • Tumor Suppressor Proteins
  • Extracellular Signal-Regulated MAP Kinases
  • MAPK15 protein, human