Objective: The aim of this meta-analysis was to analysis the expression of livin in human osteosarcoma.
Methods: We searched the Pubmed, Science Direct, Embase and Web of Science, CNKI, Wanfang and VIP for relevant original studies. Statistical analysis was performed by Stata 11.0 software.
Results: Our study indicated that livin expressed in the osteosarcoma tissue was significantly higher than the control group (OR = 18.814, P c = 0.000, 95% CI: 10.973-32.257), and the positive expression of livin was correlated with the size of osteosarcoma tumor and Enncking staging (OR = 4.832, 95% CI: 2.198-10.621; OR = 4.851, 95% CI: 3.053-7.709, respectively).
Conclusion: Livin was highly expressed in osteosarcoma, and osteosarcoma Enncking staging and tumor size were positively correlated, both may be involved in the occurrence and development of osteosarcoma, and be closely related to the prognosis of osteosarcoma patients.
Keywords: Livin; Meta-analysis; Osteosarcoma; Therapeutic target.