Emerging Development of Microfluidics-Based Approaches to Improve Studies of Muscle Cell Migration

Tissue Eng Part B Rev. 2019 Feb;25(1):30-45. doi: 10.1089/ten.TEB.2018.0181. Epub 2018 Oct 31.


The essential interactions between and among cells in the three types of muscle tissue in development, wound healing, and regeneration of tissues, are underpinned by the ability of cardiac, smooth, and skeletal muscle cells to migrate in maintaining functional capacity after pathologies such as myocardial infarction, tissue grafting, and traumatic and postsurgical injury. Microfluidics-based devices now offer significant enhancement over conventional approaches to studying cell chemotaxis and haptotaxis that are inherent in migration. Advances in experimental approaches to muscle cell movement and tissue formation will contribute to innovations in tissue engineering for patching wound repair and muscle tissue replacement.

Keywords: cardiomyocyte; microfluidics; migration; myoblast; skeletal muscle; smooth muscle.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement*
  • Humans
  • Microfluidics / methods*
  • Muscle, Skeletal / cytology
  • Muscle, Skeletal / physiology*
  • Regeneration*
  • Tissue Engineering / methods*
  • Wound Healing