Intestinal Crypts Assume the Fetal Position in Response to Injury

Cell Stem Cell. 2018 Aug 2;23(2):158-159. doi: 10.1016/j.stem.2018.07.013.


Distinct stem/progenitor cells generate intestinal epithelium during fetal and postnatal life. In a recent issue of Nature, Nusse and Savage et al. use helminth infection to show that Lgr5+ intestinal stem cells are replaced by fetal-like progenitors following injury, suggesting that some fetal developmental pathways are repurposed during injury-induced tissue regeneration.

Publication types

  • Comment

MeSH terms

  • Animals
  • Helminths*
  • Intestinal Mucosa
  • Intestines
  • Regeneration
  • Stem Cell Niche*
  • Stem Cells